My wife of 23 years says she's all for me having a hobby and approves of my guitars. However I often get "the look" when I am playing, like I'm supposed to be doing something else and I have to ask her "Is there something I'm supposed to be doing today?". She'll either say no and walk off or say "I thought you were going to fix the roof", or "I thought you were going to get gas in my car" in which case she will storm off, which makes me feel apprehencious about whether or not she approves.
I have asked her repeatedly if it's ok and she adamantly says yes. She does question why I need so many (I have six and they all fill a need - I like to play Hendrix stuff on an electric, bluegrass on a dread, Bach on a classical, etc). And of course, she questions why I need to spend so much per guitar (as another poster mentioned). When she does that I just ask her how much she has invested in purses and she'll shut up.
I never play anything for her because if it's later than 1965 she isn't interested in it, or says she hasn't heard of it. I've tried playing Hotel California and Stairway to Heaven for her (both of which I play pretty well) and she says she doesn't recognize them.
Frankly, I feel like my playing and GAS are "tolerated".