Yes. I have an all-risk rider on my homeowner's policy that gives me replacement value for the specifically listed instruments. It costs about $125 per year for roughly $35K in instruments (the wife has some pricey pro-grade flutes). If you are using instruments commercially (being paid to play) the homeowner's option may be void and you might have to use one of the commercial insurers at higher rates. The general homeowner's policy covers them at home, but with our normal deductible.
An interesting aside: I asked my agent recently about shipping coverage, since I'm planning to sell some guitars in my signature. He told me in an email that listed instruments are covered 100% right up until the addressee signs for delivery. The "insurance" that UPS, Fedex, etc sells only raises their liability payout limit in case of package loss, but will not generally pay to repair damage or restore devaluation due to damage. It is a lot like rental car "insurance" that way - almost always secondary to your own car policy.